Ninurta Galaxy
The Ninurta Galaxy is surrounded in a physics engine that ultimately resembles a video game. In the sense that most sentient creatures have the ability to level up and acquire new abilities. Through the goddess Nib it is magically tied to the Milky way galaxy and the planar stack of Na'Endreth. Occasionally souls are pulled into this world as heroes given a second chance at life.
The Galaxy is wide spread and teaming with life. Human interference here is a by-product of centuries of Isekai scenarios. By now humans have had at least 1000 years of evolution in this strange multiverse. Twisting many to the environment as new species over generations. Leaving others to adapt through technology.