Ana Amari killed by Amelie Lacroix

Life, Death

"She remained on active duty well into her fifties, until she was believed to have been killed during a hostage rescue mission by the Talon operative known as Widowmaker."   source: https://playoverwatch.com/en-us/heroes/ana/

"Well into her fifties" but also Jack was on the mission where she was shot, so it couldn't have been later than 2070, and at most she could have been 54.   source: https://playoverwatch.com/en-us/media/stories/legacy/