"Behold, the Beast of Hunger lumbers forth from its blood-soaked den, that it may slake its dark thirsts upon all the lands of the world.— Grriszyr Splitface
Theme
The plight of the stranger and the outsider. The struggle to do the right thing in the face of prejudice, to help those who will not thank you for your heroic deeds. The sacrifice of the outcast hero.
Focused Features: Central Story/Quest (with occasional branching subplots), Cinematic Three Pillar Play, Overland/Planar Exploration (In Edras read 'planes' as 'planets'), Dungeon Delving, Epic Fights, Army/Alliance Building, Faith and Religion (relationships with gods, scions, churches, etc.)
Deemphasized Features: Political Intrigue/Court Life, Downtime Actions (Crafting/Strongholds/Etc.), Resource Management, Exploration of Character Backstory (which is not to say that backstory isn't important, it absolutely will be for finding allies, contacts, information, and some subplots, but storylines will not be built around deep jumps into your characters' families or old enemies or unfinished quests)
The type of characters that will fit in this campaign: Rough and tumble men (and women) existing on the edge of society (or maybe even outside it). They have good, nobles hearts, but may be outwardly callous or devil-may-care as a result of wrongs they have seen and experienced. Their defining trait is their inability to truly belong to a society that looks at them sideways, though they find fulfilling companionship in their fellow outcasts. How they relate to the world around them is at the core of their story.
Perhaps they have soft hearts and are constantly sacrificing themselves to show the world that not all who wander are lost and that even progeny can be honorable and heroic. Perhaps they serve society begrudgingly, hating the prejudice of the Soulborn (progeny and culled alike), but still driven by an inner fire to 'do the right thing' and 'save the day', albeit with no shortage of sarcasm and a conspicuous trail of bodies in their wake. Perhaps they are the jester, laughing off the disdain from 'people of proper birth' and reveling in the freedom of the outcast and the outlaw, though perhaps also quietly seeking the approval of that which they mock.
These characters are the Magnificent Seven/the Seven Samurai, the Man With No Name, Yojimbo, Snake Plisken, the Mandalorian, the Black Company, Mad Max, El Mariachi, Cassian Andor, Ahsoka Tano, Han Solo, Riddick, Wolverine, or even for some 80s nostalgia - the Breakfast Club.
I think that Geralt of Rivia is a good archetype for this sort of story. People are very happy to see him show up to right wrongs and slay monsters. But when he's done, more often than not, the people would rather he just move along and leave their newly peaceful region. Occasionally the people in power and the characters that really matter will understand his sacrifice and appreciate him for it, but most of the time it's, 'thanks for the help, here's your gold, now beat it, freak!'.
Character Generation
Vile Appetites Primer