Lois was Embraced in the 1950 Meat Market by William after a lengthy debate between William and Cyrus. Eventually Cyrus was persuaded to other prey and Lois was entranced by the intense amount of things William said he could teach her. Unlike her sibling Jessie before her, Lois quickly became William's lover and the two were quietly content until that ill-fated night in November, 1971.

When William's Blood changed, he changed. No longer the man Lois fell in love with, the beautifully inhuman stranger before her was foreign and different in subtle but significant ways. Her unspoken and deeply held belief is that her revulsion drove him to Torpor, and she mourns to this day.

Unable to finish her Fledgling period with her Sire, she instead trained with her Sire's sibling Grace under Hiram. In his tutelage Lois began to study Blood Alchemy and Kindred Necromancy, from Hiram and Gio respectively. eventually joining the Ordo Dracul to further her pursuit of these mysteries.

Lois had paid the Headhunters to seek out the descendant of one of William's early trysts with humans during the War for Chicagoland. It paid off in 2010. Lois paid a handsome sum for the girl Julia.