The Silver Purge

"With fire and silver did the clerics of the Flame go about about their work, the purging from Khorvaire of all Lycanthropes, and a good deal of shifters as well. They carried this out with no feeling of who they might be effecting, whether these people-for they were people-deserved their fate."

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The Darkness of the Flame: The Purge Told by a Survivor by professor Ruby Silvermane, Shifter professor of Morgrave University

The Inquisition to wipe out lycanthropes (aka the Silver Purge) is launched by the Church of the Silver Flame. Over the course of the next 50 years, virtually all Lycanthropes on the continent are slain.