Plague / Epidemic
It is unknown where the Dimensional Blight came from, but it is known that it arrived in Ur in the year 282 and ravaged the city for 19 years. The Blight used to affect everything, but the efforts of the Clock Tower allowed it to be mutated - making it less virulent and only affect the inanimate. Confined to The Nest there has been little research into wiping it out completely, The Maw will get it in the end.