A large, powerful band of orcs attacks Wave Echo Cave and the nearby city of Phandalin laying waste to both. The Forge of Spells is lost and none are able to discover its location.
Monsters pushed out of Neverwinter head to Thundertree, a minor settlement that lacks the resources to defend themselves.
Pushed out of Neverwinter, the creatures of the cataclysm infect Neverwinter Wood like a disease and it becomes unsafe to travel near it. Neverwinter begins its campaign to purge the creatures from existence.
The dragons of Faerun go on a murderous rampage, killing everything in their paths including each other. Even the benevolent dragons became violent beasts. Nothing is known about the cause. It lasts for an entire year and at the end dragons become nearly extinct and go from common sightings to mere rumors. Many see this as a blessing for humanoids, but some see it as an omen for the future.
A year-long meteor storm showers the entire continent day and night. There are rumors all over the land of people finding some of the meteorites that made landfall. Nothing is known about the cause.
Hungry for new resources to rebuild itself, Neverwinter officially funds the resettlement of the mining town Phandalin to begin harvesting raw materials from the mountains.
A family of dwarves and a party of adventurers rediscover the Forge of Spells in Wave Echo Cave and clear out the opposition. The dwarves are able to reopen the door to the forge and Phandalin is on its way to prosperity once again.