The Shakes
A mysterious illness that swept the Noble Court in Tinker and Tailormoon 1313. It was particularly incurable due to its interplanar nature.
Causes
The Shakes was being deliberately spread among the Nobility of the court by the Pairaka (Fake-Yvette), who was maskerading as Yvette, the Courtesan.
Symptoms
Shakes and twitches followed by lowered Dexterity (each morning, the afflicted must make a constitution saving throw to stave off the Dexterity damage). The shaking of the sufferer is the result of the apocalyptic energy of the Div infecting their soul, which jags and thrashes in time with the shakes.
Treatment
The shakes must be treated with a Remove Curse spell or similar, before the actual disease is possible to cure. Once the curse is removed, the disease may either get better on its own (if the sufferer succeeds on two consecutive DC 13 Fortitude saving throws) or with a Remove Disease effect.